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Edward Mills is here Last month’s meeting, the data was very good.The clinical trial experts at McMaster University Mills are Present The new results of a trial that is studying the effects of six different drugs in the treatment of Covid-19-not for people who are very sick in the emergency room or hospital, but for people whose symptoms are not so severe. In other words, people who are sick at home.

In his online speech by the National Institutes of Health, Mills’ slides told a story: Relatively safe, familiar, and inexpensive drugs Reduced the relative risk of mild Covid deterioration by nearly 30%.The medicine is Fluvoxamine, A selective serotonin reuptake inhibitor-an antidepressant. (It is also an anti-inflammatory drug, inflammation and an over-reactive immune system are signs of a serious Covid infection, so this may be the reason why it seems to be helpful). Find a group of people infected with Covid and randomly divide them into two groups; 739 people take fluvoxamine and 733 people take placebo. Only 77 people taking fluvoxamine ended up in the hospital; 109 people in the placebo group did so. This is really exciting.

“Is this the first time these results have been presented in a public forum?” asked Adrian Hernandez, the host and director of the Duke Clinical Institute.

“Yes,” Mills replied. “This is the first time you have heard it.”

“Well, to put it simply, wow,” Hernandez said. If the data confirms it, it will only be the second repurposed drug suitable for outpatient Covid-19. (the other is A steroid called budesonide; Other drugs that you may have heard of, such as Remdesivir or Dexamethasone, are suitable for severely ill and hospitalized patients. ) result Has not been peer-reviewed or officially published, but Together Mills is a co-chief investigator whose trial is well-designed and respected. Now, it needs to be clear that fluvoxamine is still a long way from becoming part of the standard of care for Covid-19 patients. Once the results of the Together trial are published, guideline development organizations such as the U.S. Food and Drug Administration and the World Health Organization will have to think about it. But the Together test data, if it holds, seems positive for SSRI.

But wait! there are more!In the same speech, the same test showed that this antidepressant might reduce the symptoms of Covid-19 return Indicates the antiparasitic drug ivermectin-you have heard of that, right? ——Not helpful at all. In the Together trial, the drug commonly used to treat diseases such as river blindness and intestinal roundworms did not discharge Covid patients better than a placebo. Among the 677 Covid patients, who ate 400 micrograms per kilogram of body weight per day for three consecutive days, 86 of them ended up in the emergency room or hospital; of the 678 people who received a placebo, 95 went. This was not a significant difference, and Mills’ team removed it from the study. (I should add that vaccination is still the most effective, safest, cheapest and easiest way to avoid illness.)

Ivermectin has some Promising early results Fights the virus in petri dishes and smaller observational studies, but it still fails the test.Of the two obvious large-scale confirmations of its impact, one (a preprint by Egyptian researchers) received Withdraw Worry about plagiarism and false data. Scientists and journalists at BuzzFeed Violation found Where the data comes from other. A separate positive review of all ivermectin data Rejected by the journal after provisional acceptance Out of concerns about research integrity and conflicts of interest, and strict Meta-analysis of all A randomized controlled trial of ivermectin against Covid found that the drug had no positive effect.U.S. Food and Drug Administration Say People should not accept it.The American Medical Association and the two pharmacist associations issued a statement It is recommended that none of their members prescribe ivermectin for Covid-19 outside of clinical trials. (Oh, and a doctor in Arkansas Give drugs to prison inmates who don’t know or agree, This is usually not what you want to be on the side of history. )

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